Testosterone Undecanoate for Sleep
Testosterone undecanoate (Aveed) is a very long-acting ester of testosterone administered by deep intramuscular injection. FDA-approved for replacement therapy in adult males with primary or hypogonadotropic hypogonadism; the injectable formulation carries a boxed warning for pulmonary oil microembolism (POME) and anaphylaxis.
Why Testosterone Undecanoate for sleep?
Testosterone undecanoate (Aveed) is a very long-acting ester of testosterone administered by deep intramuscular injection. FDA-approved for replacement therapy in adult males with primary or hypogonadotropic hypogonadism; the injectable formulation carries a boxed warning for pulmonary oil microembolism (POME) and anaphylaxis.
Sleep context: Modulating sleep architecture, slow-wave sleep depth, and circadian regulation. Testosterone Undecanoate fits this goal because its category (TRT) and benefit profile align with the underlying mechanism.
Benefits relevant to sleep
- Restoration of androgen levels in adult males diagnosed with hypogonadism per FDA-approved indications
Reference dosing by bodyweight
Anchored to the most-cited research dose (250 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 156–211 mcg |
| 60–75 kg / 132–165 lb | 191–259 mcg |
| 75–90 kg / 165–198 lb | 234–316 mcg |
| 90–105 kg / 198–231 lb | 276–374 mcg |
| >105 kg / >231 lb | 319–431 mcg |
Side effects to weigh against sleep benefit
- Pulmonary oil microembolism (POME): coughing, urge to cough, dyspnea, syncope immediately post-injection (boxed warning)
- Anaphylaxis (boxed warning; REMS program required for Aveed)
- Erythrocytosis/polycythemia
- Acne and oily skin
- Injection site reactions
- Suppression of spermatogenesis and reduced fertility
- Gynecomastia (via aromatization)
- Edema and fluid retention
- Prostate-related effects
- Adverse changes in lipid profile
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.