What is the typical research dose of Gonadorelin for recovery?

100 mcg single sc or iv bolus, Per historical Factrel labeling; LH sampled at baseline and timed intervals.

Performance · For Recovery

Gonadorelin for Recovery

Q: Is Gonadorelin researched for recovery?

Gonadorelin is a Performance compound. Synthetic decapeptide identical to endogenous GnRH that stimulates the pituitary to release LH and FSH; used diagnostically and, off-label, to support the gonadal axis during testosterone therapy. For recovery specifically, the relevant mechanism is accelerating soft-tissue, tendon, gut, and post-training repair.

Synthetic decapeptide identical to endogenous GnRH that stimulates the pituitary to release LH and FSH; used diagnostically and, off-label, to support the gonadal axis during testosterone therapy.

Why Gonadorelin for recovery?

The 100 mcg single-bolus test is validated for assessing pituitary gonadotrope reserve. Pulsatile pump regimens are established for ovulation induction. The popular off-label use to preserve fertility and testicular size during testosterone therapy relies on mechanistic extrapolation and small clinical reports rather than large randomized trials, and is constrained by gonadorelin's very short half-life. According to PubMed, pharmacokinetics differ markedly by route (Handelsman DJ et al., J Clin Endocrinol Metab 1984).

Recovery context: Accelerating soft-tissue, tendon, gut, and post-training repair. Gonadorelin fits this goal because its category (Performance) and benefit profile align with the underlying mechanism.

Benefits relevant to recovery

Stimulates pituitary release of LH and FSH (approved diagnostic use)
Pulsatile dosing can induce ovulation in hypothalamic amenorrhea (historical approved use)
Off-label and educational: may help maintain testicular volume and intratesticular testosterone in men on exogenous testosterone (not FDA-approved for this use)

Reference dosing by bodyweight

Anchored to the most-cited research dose (100 mcg @ 75 kg). Reference only.

Bodyweight band	Reference dose range
<60 kg / <132 lb	62–84 mcg
60–75 kg / 132–165 lb	77–103 mcg
75–90 kg / 165–198 lb	94–126 mcg
90–105 kg / 198–231 lb	111–150 mcg
>105 kg / >231 lb	128–173 mcg

Side effects to weigh against recovery benefit

Headache
Flushing
Nausea
Injection-site reactions
Rare hypersensitivity reactions

Calculator

Reconstitute Gonadorelin

Reference

Full bodyweight chart

Profile

Gonadorelin guide

Also researched for

Gonadorelin for Muscle Gain

Educational use only

This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.