Human Beta-Defensin 2 (hBD-2) for Recovery
Inducible antimicrobial peptide active against Gram-negative bacteria and Candida.
Why Human Beta-Defensin 2 (hBD-2) for recovery?
Human beta-defensin 2 (hBD-2, DEFB4) is a 41-aa cationic antimicrobial peptide induced in epithelia by IL-1, TNF, and bacterial products. Active against Gram-negative bacteria, fungi, and some enveloped viruses; also a CCR6 ligand recruiting dendritic cells. Studied as a topical anti-infective; no approved indication.
Recovery context: Accelerating soft-tissue, tendon, gut, and post-training repair. Human Beta-Defensin 2 (hBD-2) fits this goal because its category (Other) and benefit profile align with the underlying mechanism.
Benefits relevant to recovery
- Topical wound and skin uses
Reference dosing by bodyweight
Anchored to the most-cited research dose (250 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 156–211 mcg |
| 60–75 kg / 132–165 lb | 191–259 mcg |
| 75–90 kg / 165–198 lb | 234–316 mcg |
| 90–105 kg / 198–231 lb | 276–374 mcg |
| >105 kg / >231 lb | 319–431 mcg |
Side effects to weigh against recovery benefit
- Pro-inflammatory at supraphysiologic doses
- Limited clinical data
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.