Humanin for Longevity
Mitochondrial-derived peptide that protects against amyloid-beta and metabolic stress.
Why Humanin for longevity?
Humanin is a 24-aa peptide encoded within the mitochondrial 16S rRNA region, discovered by Hashimoto et al. (2001) as a factor protecting neurons from amyloid-beta-induced toxicity. Together with MOTS-c and the SHLPs, it is part of the mitochondrial-derived peptide family. Studied in Alzheimer's, atherosclerosis, and diabetes models; no approved indication.
Longevity context: Targeting senescent cells, mitochondrial function, telomere maintenance, and cellular resilience. Humanin fits this goal because its category (Longevity) and benefit profile align with the underlying mechanism.
Benefits relevant to longevity
- Cytoprotective in mitochondrial stress
Reference dosing by bodyweight
Anchored to the most-cited research dose (250 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 156–211 mcg |
| 60–75 kg / 132–165 lb | 191–259 mcg |
| 75–90 kg / 165–198 lb | 234–316 mcg |
| 90–105 kg / 198–231 lb | 276–374 mcg |
| >105 kg / >231 lb | 319–431 mcg |
Side effects to weigh against longevity benefit
- Limited human safety data
- Theoretical immunogenicity
Also researched for
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.