Is IGF-1 DES researched for muscle gain?

IGF-1 DES is a Performance compound. Truncated IGF-1 with localized hypertrophic action; favored for site-specific bodybuilding research. For muscle gain specifically, the relevant mechanism is increasing lean mass via gh/igf-1 axis, satellite-cell activity, or anabolic signaling.

What is the typical research dose of IGF-1 DES for muscle gain?

20–50 mcg post-workout, Intramuscular, target site.

What side effects of IGF-1 DES matter most when used for muscle gain?

Hypoglycemia risk; Local site swelling

Performance · For Muscle Gain

IGF-1 DES for Muscle Gain

Truncated IGF-1 with localized hypertrophic action; favored for site-specific bodybuilding research.

Why IGF-1 DES for muscle gain?

Des(1-3) IGF-1 lacks the first three residues; ~10× more potent at the IGF-1R locally because it doesn't bind IGFBPs. Short systemic half-life.

Muscle Gain context: Increasing lean mass via GH/IGF-1 axis, satellite-cell activity, or anabolic signaling. IGF-1 DES fits this goal because its category (Performance) and benefit profile align with the underlying mechanism.

Benefits relevant to muscle gain

Localized muscle hyperplasia

Reference dosing by bodyweight

Anchored to the most-cited research dose (30 mcg @ 75 kg). Reference only.

Bodyweight band	Reference dose range
<60 kg / <132 lb	19–25 mcg
60–75 kg / 132–165 lb	23–31 mcg
75–90 kg / 165–198 lb	28–38 mcg
90–105 kg / 198–231 lb	33–45 mcg
>105 kg / >231 lb	38–52 mcg

Side effects to weigh against muscle gain benefit

Hypoglycemia risk
Local site swelling

Calculator

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Reference

Full bodyweight chart

Profile

IGF-1 DES guide

Also researched for

IGF-1 DES for Recovery

Educational use only

This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.