MGF (Mechano Growth Factor) for Muscle Gain
IGF-1Ec splice variant released by mechanical loading; activates muscle satellite cells.
Why MGF (Mechano Growth Factor) for muscle gain?
MGF is a splice variant of IGF-1 (IGF-1Ec) produced in muscle in response to mechanical overload or damage. It is distinct from systemic IGF-1 and acts in a paracrine fashion to recruit satellite cells. Synthetic PEG-MGF extends its very short half-life from minutes to hours and is the form most commonly used in research.
Muscle Gain context: Increasing lean mass via GH/IGF-1 axis, satellite-cell activity, or anabolic signaling. MGF (Mechano Growth Factor) fits this goal because its category (Performance) and benefit profile align with the underlying mechanism.
Benefits relevant to muscle gain
- Satellite cell activation
- Local muscle hypertrophy
Reference dosing by bodyweight
Anchored to the most-cited research dose (200 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 125–169 mcg |
| 60–75 kg / 132–165 lb | 153–207 mcg |
| 75–90 kg / 165–198 lb | 187–253 mcg |
| 90–105 kg / 198–231 lb | 221–299 mcg |
| >105 kg / >231 lb | 255–345 mcg |
Side effects to weigh against muscle gain benefit
- Local hypoglycemia (rare)
- Injection-site irritation
- Short half-life requires frequent dosing
Also researched for
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.