Metabolic · For Fat Loss
Tesofensine for Fat Loss
Triple monoamine reuptake inhibitor with strong weight-loss data; not FDA-approved.
Why Tesofensine for fat loss?
Phase III trial (2010) showed ~10% weight loss at 0.5 mg/day. Original Alzheimer's program scrapped; revived for obesity in some regions (Mexico, Argentina).
Fat Loss context: Reducing body fat percentage through appetite regulation, lipolysis, or metabolic upregulation. Tesofensine fits this goal because its category (Metabolic) and benefit profile align with the underlying mechanism.
Benefits relevant to fat loss
- Significant weight loss
- Appetite suppression
Reference dosing by bodyweight
Anchored to the most-cited research dose (250 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 156–211 mcg |
| 60–75 kg / 132–165 lb | 191–259 mcg |
| 75–90 kg / 165–198 lb | 234–316 mcg |
| 90–105 kg / 198–231 lb | 276–374 mcg |
| >105 kg / >231 lb | 319–431 mcg |
Side effects to weigh against fat loss benefit
- Insomnia
- Increased heart rate
- Dry mouth
- Mood effects
Calculator
Reconstitute Tesofensine
Reference
Full bodyweight chart
Profile
Tesofensine guide
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.