Tesofensine + Metoprolol (Tesomet) for Fat Loss
Tesofensine paired with metoprolol (Tesomet) to control HR while preserving weight loss.
Why Tesofensine + Metoprolol (Tesomet) for fat loss?
Tesomet is a fixed-dose combination of tesofensine (a triple monoamine reuptake inhibitor) with metoprolol developed by Saniona. The metoprolol component is intended to blunt cardiovascular activation while maintaining the weight-loss efficacy of tesofensine. Phase 2 trials in hypothalamic obesity and Prader-Willi syndrome reported significant weight loss.
Fat Loss context: Reducing body fat percentage through appetite regulation, lipolysis, or metabolic upregulation. Tesofensine + Metoprolol (Tesomet) fits this goal because its category (Metabolic) and benefit profile align with the underlying mechanism.
Benefits relevant to fat loss
- Preserves weight loss
- Studied in Prader-Willi and hypothalamic obesity
Reference dosing by bodyweight
Anchored to the most-cited research dose (500 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 312–422 mcg |
| 60–75 kg / 132–165 lb | 383–518 mcg |
| 75–90 kg / 165–198 lb | 468–633 mcg |
| 90–105 kg / 198–231 lb | 553–747 mcg |
| >105 kg / >231 lb | 638–862 mcg |
Side effects to weigh against fat loss benefit
- Sleep disturbance
- Dry mouth
- Mood changes
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.