ARA-290 (Cibinetide) + MK-677 (Ibutamoren) stack
A research-context overview of stacking ARA-290 (Cibinetide) with MK-677 (Ibutamoren): the rationale, complementary benefits, side-effect overlap, and pharmacokinetic considerations. Educational only, never a recommendation.
Why this stack?
Pairing a Performance peptide like MK-677 (Ibutamoren) with a Recovery peptide like ARA-290 (Cibinetide) is one of the most common stack archetypes in the research literature. The Performance compound drives the GH/IGF-1 axis or anabolic signaling; the Recovery compound shortens the soft-tissue and inflammation tax of training, letting the anabolic signal land on healthier tissue. The two work on independent pathways, so timing concerns are minimal, most researchers dose them on separate clocks.
ARA-290 (Cibinetide)
Investigational 11-amino-acid peptide derived from the helix-B region of erythropoietin that activates the innate repair receptor without stimulating red-blood-cell production; studied for small-fiber neuropathy.
Key benefits
- Activates the innate repair receptor to promote tissue protection and healing
- Reduced neuropathic pain symptoms in sarcoidosis small-fiber neuropathy trials
- Increased corneal nerve fiber measures (a marker of small-nerve regeneration) without raising hematocrit
Side effects to watch
- Generally well tolerated in trials
- Injection-site reactions
- Long-term safety not established
MK-677 (Ibutamoren)
Oral GH secretagogue that cranks appetite, muscle preservation, and bone density.
Key benefits
- Increases muscle mass
- Improves bone density
- Improves sleep quality
- Oral administration
Side effects to watch
- Increased appetite
- Water retention
- Lethargy
Half-life considerations
Reference half-life data for one or both of these compounds is not in our table, see the individual peptide profiles for cited PK ranges.
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.