Epithalamin for Sleep
Pineal-gland polypeptide extract; predecessor of Epitalon used in Russian gerontology.
Why Epithalamin for sleep?
Epithalamin is a pineal polypeptide extract from calf pineal gland developed in the Soviet Union by Khavinson and Anisimov from the 1970s. Reported to extend lifespan in mice, rats, and Drosophila in long-running St. Petersburg studies. The synthetic tetrapeptide Epitalon (Ala-Glu-Asp-Gly) was developed as the chemically defined successor.
Sleep context: Modulating sleep architecture, slow-wave sleep depth, and circadian regulation. Epithalamin fits this goal because its category (Longevity) and benefit profile align with the underlying mechanism.
Benefits relevant to sleep
- Melatonin-axis modulation
Reference dosing by bodyweight
Anchored to the most-cited research dose (10000 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 6233–8433 mcg |
| 60–75 kg / 132–165 lb | 7650–10350 mcg |
| 75–90 kg / 165–198 lb | 9350–12650 mcg |
| 90–105 kg / 198–231 lb | 11050–14950 mcg |
| >105 kg / >231 lb | 12750–17250 mcg |
Side effects to weigh against sleep benefit
- Limited Western safety data
- Animal-derived extract concerns
Also researched for
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.