GDF-11 for Sleep
TGF-beta family ligand controversially linked to age-reversal via parabiosis studies.
Why GDF-11 for sleep?
GDF-11 (Growth Differentiation Factor 11) is a TGF-beta family member famously linked to reversal of cardiac hypertrophy in parabiosis experiments by Amy Wagers' lab (2013). Subsequent work by Novartis/Glass et al. (2015) disputed the original assays and showed GDF-11 can be myo-inhibitory like myostatin. Therapeutic role remains controversial.
Sleep context: Modulating sleep architecture, slow-wave sleep depth, and circadian regulation. GDF-11 fits this goal because its category (Longevity) and benefit profile align with the underlying mechanism.
Benefits relevant to sleep
- Possible muscle/cardiac rejuvenation (debated)
- Neurogenesis (preclinical)
Reference dosing by bodyweight
Anchored to the most-cited research dose (250 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 156–211 mcg |
| 60–75 kg / 132–165 lb | 191–259 mcg |
| 75–90 kg / 165–198 lb | 234–316 mcg |
| 90–105 kg / 198–231 lb | 276–374 mcg |
| >105 kg / >231 lb | 319–431 mcg |
Side effects to weigh against sleep benefit
- Muscle wasting at high doses
- Activin receptor cross-reactivity
Also researched for
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.