GDF-11
TGF-beta family ligand controversially linked to age-reversal via parabiosis studies.
No acute perceptible effect; intended for long-term cellular outcomes rather than immediate changes.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
GDF-11 (Growth Differentiation Factor 11) is a TGF-beta family member famously linked to reversal of cardiac hypertrophy in parabiosis experiments by Amy Wagers' lab (2013). Subsequent work by Novartis/Glass et al. (2015) disputed the original assays and showed GDF-11 can be myo-inhibitory like myostatin. Therapeutic role remains controversial.
Citations (4)
- The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in tissue specific agingPubMed
- Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular DiseaseReview
- Reduced Circulating GDF11 Is Unlikely Responsible for Age-Dependent Changes in Mouse Heart, Muscle, and BrainPubMed
- GDF11 Increases with Age and Inhibits Skeletal Muscle RegenerationReview
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Research Protocols
Common DosagesResearch
“Animal studies 0.1 mg/kg/day IP”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Key Research Benefits
- Possible muscle/cardiac rejuvenation (debated)
- Neurogenesis (preclinical)
Potential Side Effects
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 0.10 mL on a U-100 syringe
GDF-11 by goal
Read GDF-11's profile filtered through specific research goals.
Related Tools
Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.