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111 compounds across peptides, hormones, and small molecules. 52 have full evidence profiles with mechanism summaries, evidence grades, and peer-reviewed citations. Information is for educational purposes only.
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Showing 11 of 111 compounds (3 with full profiles)
Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide developed as the chemically defined form of the pineal polypeptide extract Epithalamin.
Pineal-gland polypeptide extract; predecessor of Epitalon used in Russian gerontology.
Senolytic D-retro-inverso peptide that disrupts FOXO4-p53 to selectively kill senescent cells.
TGF-beta family ligand controversially linked to age-reversal via parabiosis studies.
Antioxidant Powerhouse.
Mitochondrial-derived peptide that protects against amyloid-beta and metabolic stress.
Anti-aging hormone; soluble klotho boosts cognition and modulates phosphate/FGF23 axis.
MOTS-c is a mitochondria-derived peptide encoded by the 12S rRNA region of mitochondrial DNA.
Khavinson tripeptide (Glu-Asp-Arg) marketed for pineal/CNS gerontoprotection.
SS-31 (Elamipretide / MTP-131) is a cell-permeable aromatic-cationic tetrapeptide that selectively targets the inner mitochondrial membrane via electrostatic and hydrophobic interactions with cardiolipin.
Khavinson tripeptide (Lys-Glu-Asp) marketed as a vascular bioregulator.
