Klotho (alpha-Klotho)
Anti-aging hormone; soluble klotho boosts cognition and modulates phosphate/FGF23 axis.
No acute perceptible effect; intended for long-term cellular outcomes rather than immediate changes.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Alpha-Klotho is a single-pass transmembrane protein with a shed soluble form that acts as a circulating hormone. Klotho-overexpressing mice live ~30% longer; klotho-deficient mice age prematurely. Dena Dubal's lab (UCSF, 2014, 2020) showed that exogenous soluble klotho improves cognition in aged mice and primates. Human trials remain limited.
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Research Protocols
Common DosagesResearch
“Animal studies 10-30 mcg/kg SC”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Key Research Benefits
- Cognitive enhancement (preclinical)
- Phosphate homeostasis
- Anti-fibrotic in kidney models
Potential Side Effects
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
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Klotho (alpha-Klotho) by goal
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.