Klotho (alpha-Klotho) for Sleep
Anti-aging hormone; soluble klotho boosts cognition and modulates phosphate/FGF23 axis.
Why Klotho (alpha-Klotho) for sleep?
Alpha-Klotho is a single-pass transmembrane protein with a shed soluble form that acts as a circulating hormone. Klotho-overexpressing mice live ~30% longer; klotho-deficient mice age prematurely. Dena Dubal's lab (UCSF, 2014, 2020) showed that exogenous soluble klotho improves cognition in aged mice and primates. Human trials remain limited.
Sleep context: Modulating sleep architecture, slow-wave sleep depth, and circadian regulation. Klotho (alpha-Klotho) fits this goal because its category (Longevity) and benefit profile align with the underlying mechanism.
Benefits relevant to sleep
- Cognitive enhancement (preclinical)
- Phosphate homeostasis
- Anti-fibrotic in kidney models
Reference dosing by bodyweight
Anchored to the most-cited research dose (250 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 156–211 mcg |
| 60–75 kg / 132–165 lb | 191–259 mcg |
| 75–90 kg / 165–198 lb | 234–316 mcg |
| 90–105 kg / 198–231 lb | 276–374 mcg |
| >105 kg / >231 lb | 319–431 mcg |
Side effects to weigh against sleep benefit
- Theoretical phosphate disturbance
- Unstudied chronic dosing in humans
Also researched for
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.