MOTS-c
MOTS-c is a mitochondria-derived peptide encoded by the 12S rRNA region of mitochondrial DNA. It has been studied for its role as an exercise-responsive myokine that activates AMPK pathways, improving insulin sensitivity and glucose metabolism. Reduced MOTS-c levels have been observed in preclinical models of insulin resistance, and exogenous administration has been shown to reverse diet-induced obesity in mice.
No acute perceptible effect; intended for long-term cellular outcomes rather than immediate changes.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-aa peptide encoded in mtDNA. Improves AMPK signaling and skeletal-muscle glucose uptake.
Pharmacokinetics
- Half-life (t½)
- 4 h
- Approximate plasma half-life
- Routes
- Subcutaneous
Citations (6)
- Reduced serum and skeletal muscle MOTS-c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunctionPubMed 2026
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistancePubMed
- The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivityPubMed
- MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolismReview
- Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and agingPubMed
- An 8-Week study on the effects of high and Moderate-Intensity interval exercises on mitochondrial MOTS-C changes and their relation to metabolic markers in male diabetic sand ratsPubMed
Last reviewed: 2026-05-09
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Typical Dose Range Observed
Research Protocols
Common DosagesMetabolic Cycle
“Often cycled 8–12 weeks”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Studied for AMPK-mediated insulin sensitivity and glucose uptake in metabolic research
- Investigated as a candidate for metabolic syndrome and type 2 diabetes research
- Explored for mitochondrial biogenesis and anti-aging research applications
Key Research Benefits
- Boosts metabolism
- Insulin sensitization
- Mitochondrial efficiency
- Endurance support
Potential Side Effects
Considerations and Cautions
- Very limited human clinical data; investigational only
- Long-term safety profile not established
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
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MOTS-c by goal
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.