Longevity · For Longevity
MOTS-c for Longevity
Mitochondrial-derived peptide that improves insulin sensitivity and exercise capacity.
Why MOTS-c for longevity?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-aa peptide encoded in mtDNA. Improves AMPK signaling and skeletal-muscle glucose uptake.
Longevity context: Targeting senescent cells, mitochondrial function, telomere maintenance, and cellular resilience. MOTS-c fits this goal because its category (Longevity) and benefit profile align with the underlying mechanism.
Benefits relevant to longevity
- Mitochondrial efficiency
Reference dosing by bodyweight
Anchored to the most-cited research dose (5000 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 3117–4217 mcg |
| 60–75 kg / 132–165 lb | 3825–5175 mcg |
| 75–90 kg / 165–198 lb | 4675–6325 mcg |
| 90–105 kg / 198–231 lb | 5525–7475 mcg |
| >105 kg / >231 lb | 6375–8625 mcg |
Side effects to weigh against longevity benefit
- Mild fatigue (rare)
- Injection site irritation
Calculator
Reconstitute MOTS-c
Reference
Full bodyweight chart
Profile
MOTS-c guide
Also researched for
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.