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111 compounds across peptides, hormones, and small molecules. 52 have full evidence profiles with mechanism summaries, evidence grades, and peer-reviewed citations. Information is for educational purposes only.
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Showing 10 of 111 compounds
Anastrozole is a potent, selective, reversible inhibitor of the aromatase enzyme (CYP19A1), which catalyzes the conversion of adrenal androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) in peripheral tissues.
Clomiphene interacts with estrogen receptors in the hypothalamus and pituitary, blocking estrogen-mediated negative feedback.
DHEA is synthesized primarily in the adrenal cortex from cholesterol.
Enclomiphene acts as an estrogen receptor antagonist primarily at hypothalamic and pituitary sites.
Pregnenolone is synthesized from cholesterol by CYP11A1 (the mitochondrial side-chain cleavage enzyme) in steroidogenic tissues including adrenal glands, gonads, and brain.
Tamoxifen and its active metabolites (4-hydroxytamoxifen and endoxifen) competitively bind estrogen receptors (ER-alpha and ER-beta).
After intramuscular or subcutaneous injection, testosterone cypionate is hydrolyzed by esterases to free testosterone.
Testosterone enanthate is hydrolyzed after injection to free testosterone, which binds the intracellular androgen receptor.
Testosterone propionate is rapidly hydrolyzed after intramuscular injection to free testosterone.
Testosterone undecanoate is a long-chain ester hydrolyzed to free testosterone after deep intramuscular injection into the gluteal muscle, providing sustained release over weeks.
