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DOSEVAULT
Longevity

FOXO4-DRI

Senolytic D-retro-inverso peptide that disrupts FOXO4-p53 to selectively kill senescent cells.

Molecular Profile
linear
30 AA Sequence
CAS
2460055-10-9
Mol. weight
5358 g/mol
Formula
D-retro-inverso FOXO4 fragment
Chain length
30 aa
Sequence
FOXO4 D-retro-inverso peptide
Onset and duration

No acute perceptible effect; intended for long-term cellular outcomes rather than immediate changes.

Storage and reconstitution

Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.

Clinical Evidence

What the literature says

Scientific Overview

FOXO4-DRI is a 30-aa D-retro-inverso peptide developed by Peter de Keizer's lab (Cell, 2017). It disrupts the FOXO4-p53 interaction in senescent cells, restoring p53 nuclear exclusion and triggering apoptosis. Mouse data showed improved fur density, fitness, and renal function. No published human trials; only research-grade material is available.

Citations (4)

  1. Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human ChondrocytesReview
  2. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged miceReview
  3. FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathwayReview
  4. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRIReview

Research Guide

How users approach this compound

The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.

Research Protocols

Common Dosages

Research only

Not established
N/A

“Pre-clinical; pulsed dosing in mice 5 mg/kg 3x/week”

Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.

Key Research Benefits

  • Selective senolysis
  • Restored fitness in aged mice
  • Hair regrowth (mouse studies)

Potential Side Effects

Unstudied in humans
Theoretical immune/cytokine reactions

Labs to monitor

Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.

  • No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.

Dose Calculator

Peptide Reconstitution Calculator

mg

Total amount of peptide in the vial.

mL

Volume of water used to mix.

mcg

Draw to this mark

10 Units

or 0.10 mL on a U-100 syringe

Concentration:2.50 mg/mL
Peptide per Unit:25.00 mcg/unit
*Always double-check your calculations. This tool is for educational purposes only.

FOXO4-DRI by goal

Read FOXO4-DRI's profile filtered through specific research goals.

FOXO4-DRI for SleepFOXO4-DRI for Longevity

Related Tools

Not medical advice

Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.