GHK-Cu
GHK-Cu (copper peptide) is a tripeptide (Gly-His-Lys) complexed with copper(II) that occurs naturally in human plasma, urine, and saliva. It has been studied for its roles in wound healing, collagen synthesis stimulation, and antioxidant activity. Research suggests it activates several hundred genes related to wound repair and tissue remodeling, with declining plasma levels observed with aging.
Topical effects build gradually over weeks of consistent use.
Store the lyophilized powder refrigerated (2 to 8 C), protected from light. After reconstitution, keep refrigerated and use within about 4 weeks. Topical formulations follow the product's own storage directions.
Clinical Evidence
What the literature says
Scientific Overview
Discovered in 1973, GHK-Cu influences over 4,000 human genes. It is a tripeptide-copper complex extensively studied for its ability to promote dermal remodeling, angiogenesis, and nerve regeneration.
Pharmacokinetics
- Half-life (t½)
- 30 min
- Approximate plasma half-life
- Routes
- SubcutaneousIntramuscular
t½ 1.0 h · ~3% remaining at 5 h
Citations (6)
- Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospectivePubMed 2025
- Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+PubMed
- The human tri-peptide GHK and tissue remodelingPubMed
- Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene DataPubMed
- The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast culturesPubMed
- GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin RegenerationReview
Last reviewed: 2026-05-09
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Typical Dose Range Observed
Research Protocols
Common DosagesCellular Repair
“Excellent for skin, hair, and tissue rejuvenation”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Studied for wound healing and skin regeneration via collagen and elastin stimulation
- Investigated as a topical anti-aging peptide for wrinkle reduction and skin firmness
- Explored for hair follicle stimulation and scalp health in cosmetic formulations
Key Research Benefits
- Boosts collagen/elastin (70%+)
- Accelerates wound healing
- Stimulates hair growth
- Reduces fine lines/wrinkles
Potential Side Effects
Considerations and Cautions
- Topical formulations generally well tolerated; systemic data limited
- Copper accumulation theoretically possible with high-dose systemic use
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 0.10 mL on a U-100 syringe
Stacks featuring GHK-Cu
Community-published protocols that include this peptide. Sorted by upvotes.
Quick Explainer
GHK-Cu by goal
Read GHK-Cu's profile filtered through specific research goals.
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.