GHRH (Growth Hormone-Releasing Hormone) for Muscle Gain
Native 44-aa hypothalamic GHRH; parent molecule of sermorelin, CJC-1295, and tesamorelin.
Why GHRH (Growth Hormone-Releasing Hormone) for muscle gain?
GHRH (somatocrinin) is the native 44-aa hypothalamic peptide that stimulates pituitary somatotrophs to release growth hormone. Recombinant full-length GHRH (Geref / sermorelin acetate prior to truncation) was historically used in pediatric GH-deficiency diagnostics. Modern analogs sermorelin (1-29), CJC-1295, and tesamorelin all derive from this parent.
Muscle Gain context: Increasing lean mass via GH/IGF-1 axis, satellite-cell activity, or anabolic signaling. GHRH (Growth Hormone-Releasing Hormone) fits this goal because its category (Performance) and benefit profile align with the underlying mechanism.
Benefits relevant to muscle gain
- Pulsatile GH release
- Preserves natural HPA axis
- Reference comparator for analogs
Reference dosing by bodyweight
Anchored to the most-cited research dose (100 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 62–84 mcg |
| 60–75 kg / 132–165 lb | 77–103 mcg |
| 75–90 kg / 165–198 lb | 94–126 mcg |
| 90–105 kg / 198–231 lb | 111–150 mcg |
| >105 kg / >231 lb | 128–173 mcg |
Side effects to weigh against muscle gain benefit
- Flushing
- Headache
- Injection-site reactions
Also researched for
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.