KPV
KPV is a C-terminal tripeptide of alpha-MSH (Lys-Pro-Val) that retains anti-inflammatory activity via interaction with melanocortin receptors and nuclear NF-kB pathway inhibition, without the pigmentation-driving activity of the full alpha-MSH sequence. It has been studied in mucosal inflammation models and demonstrated anti-inflammatory effects in colitis via intraperitoneal and oral delivery in animal studies.
No acute perceptible effect; reported benefits build over days to weeks of consistent use.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-MSH. Demonstrates anti-inflammatory effects via NF-κB modulation; oral bioavailability supports gut indications.
Pharmacokinetics
- Half-life (t½)
- 2.0 h
- Approximate plasma half-life
- Routes
- SubcutaneousOral
Citations (6)
- Self-Cross-Linked Hydrogel of Cysteamine-Grafted gamma-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in RatsPubMed 2021
- PepT1-mediated tripeptide KPV uptake reduces intestinal inflammationPubMed
- Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative ColitisPubMed
- Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine modelPubMed
- Melanocortin-derived tripeptide KPV has anti-inflammatory potential in dextran sodium sulfate-induced murine colitisPubMed
- In situ mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositisPubMed
Last reviewed: 2026-05-09
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Typical Dose Range Observed
Research Protocols
Common DosagesAnti-Inflammatory
“Oral or SC”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Studied for mucosal anti-inflammatory activity in intestinal inflammation models
- Investigated as a potential candidate for inflammatory bowel disease research
- Explored for skin anti-inflammatory applications
Key Research Benefits
- Reduces inflammation
- Gut healing (UC/IBD studies)
- Wound and acne support
Potential Side Effects
Considerations and Cautions
- Very limited human data; research-only compound
- Not approved for any clinical indication
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 0.10 mL on a U-100 syringe
Stack KPVwith…
Curated stacking partners researched alongside KPV. Each link opens a dedicated stack page with combined benefits, side-effect overlap, and half-life considerations.
- Performance stackKPV + IpamorelinGentle GH releaser that amps muscle growth and fat loss without the harsh sides.
- Performance stackKPV + CJC-1295Pairs with Ipamorelin for sustained growth hormone spikes, ideal for body comp tweaks.
- Performance stackKPV + SermorelinMimics natural GH pulses to build lean mass and improve sleep/recovery.
- Performance stackKPV + MK-677 (Ibutamoren)Oral GH secretagogue that cranks appetite, muscle preservation, and bone density.
KPV by goal
Read KPV's profile filtered through specific research goals.
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.