Cosmetic · For Sleep
PT-141 (Bremelanotide) for Sleep
Melanocortin agonist FDA-approved (Vyleesi) for HSDD; libido enhancement.
Why PT-141 (Bremelanotide) for sleep?
Bremelanotide (Vyleesi) is FDA-approved for premenopausal HSDD. Acts on MC4R in the hypothalamus.
Sleep context: Modulating sleep architecture, slow-wave sleep depth, and circadian regulation. PT-141 (Bremelanotide) fits this goal because its category (Cosmetic) and benefit profile align with the underlying mechanism.
Benefits relevant to sleep
- Increases libido
- Acts on CNS, not vascular
- Works in both sexes
Reference dosing by bodyweight
Anchored to the most-cited research dose (1000 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 623–843 mcg |
| 60–75 kg / 132–165 lb | 765–1035 mcg |
| 75–90 kg / 165–198 lb | 935–1265 mcg |
| 90–105 kg / 198–231 lb | 1105–1495 mcg |
| >105 kg / >231 lb | 1275–1725 mcg |
Side effects to weigh against sleep benefit
- Nausea
- Flushing
- BP elevation (transient)
- Headache
Calculator
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Reference
Full bodyweight chart
Profile
PT-141 (Bremelanotide) guide
Also researched for
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.