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DOSEVAULT
OtherClinical Evidence: Moderate

Thymosin Alpha-1

Thymosin Alpha-1 (Talpha1) is a 28-amino-acid acetylated peptide originally isolated from thymic tissue. It has been studied extensively as an immune modulator, with documented effects on dendritic cell maturation, T-cell activation, and NK cell activity. It is approved in multiple countries for hepatitis B and hepatitis C and has been investigated for cancer immunotherapy adjuvant use.

Molecular Profile
linear
28 AA Sequence
Evidence grade (Moderate): Small clinical studies or well-designed non-RCT human research. This grade reflects the overall quality of available research on this compound and does not constitute a clinical recommendation.
CAS
62304-98-7
Mol. weight
3108.3 g/mol
Formula
C129H215N33O55
Chain length
28 aa
Sequence
Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN
Onset and duration

Onset and duration vary by individual; see the mechanism and half-life above.

Storage and reconstitution

Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.

Clinical Evidence

What the literature says

Scientific Overview

TA-1 is a 28-aa peptide (Zadaxin) approved in 35+ countries for hepatitis B/C and as a vaccine adjuvant. Increases CD4+ T-cell function and IFN-γ.

Pharmacokinetics

Half-life (t½)
2.0 h
Approximate plasma half-life
Routes
Subcutaneous

Citations (7)

  1. Aging and Thymosin Alpha-1PubMed 2025
  2. Thymosin alpha 1 in the treatment of cancer: from basic research to clinical applicationPubMed
  3. Immune Modulation with Thymosin Alpha 1 TreatmentPubMed
  4. A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis BPubMed
  5. A randomized, controlled study of thymosin-alpha1 therapy in patients with anti-HBe, HBV-DNA-positive chronic hepatitis BPubMed
  6. From lab to bedside: emerging clinical applications of thymosin alpha 1PubMed
  7. Thymosin α-1 in cancer therapy: Immunoregulation and anti-tumor effectsPubMed

Last reviewed: 2026-05-09

Research Guide

How users approach this compound

The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.

Typical Dose Range Observed

1.6–3.2 mg
subcutaneous injection

Research Protocols

Common Dosages

Immune Support

1.6 mg
2× weekly

“SC injection; 4–12 week cycles common”

Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.

Reported Uses

  • Approved in some countries as an adjuvant immunotherapy for hepatitis B and C
  • Studied for immune modulation in chronic infections and certain cancers
  • Investigated for potential benefits in immunosenescence and aging-related immune decline

Key Research Benefits

  • T-cell modulation
  • Antiviral support
  • Adjunct in chronic infection

Potential Side Effects

Injection-site discomfort

Considerations and Cautions

  • Use in organ transplant recipients or patients on immunosuppressive therapy requires caution
  • Not FDA-approved in the United States; available under research or international protocols

Labs to monitor

Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.

  • No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.

Dose Calculator

Peptide Reconstitution Calculator

mg

Total amount of peptide in the vial.

mL

Volume of water used to mix.

mcg

Draw to this mark

64 Units

or 0.64 mL on a U-100 syringe

Concentration:2.50 mg/mL
Peptide per Unit:25.00 mcg/unit
*Always double-check your calculations. This tool is for educational purposes only.

Related Tools

Not medical advice

Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.