Thymulin for Sleep
A zinc-dependent thymic nonapeptide (FTS-Zn) that supports T-cell maturation and modulates inflammation; studied mainly in preclinical and mechanistic research.
Why Thymulin for sleep?
According to PubMed, thymulin's biological activity requires bound zinc: the zinc-free peptide is inactive and zinc restores activity, defining the active 'thymulin' (FTS-Zn) form (Dardenne M et al., PNAS 1982). Serum thymulin activity falls in human zinc deficiency and is restored by zinc supplementation, making it a sensitive marker of zinc status (Prasad AS et al., J Clin Invest 1988). Most therapeutic work is preclinical or mechanistic; dedicated human efficacy trials are sparse.
Sleep context: Modulating sleep architecture, slow-wave sleep depth, and circadian regulation. Thymulin fits this goal because its category (Recovery) and benefit profile align with the underlying mechanism.
Benefits relevant to sleep
- Supports T-cell differentiation and thymic immune function (preclinical)
- Anti-inflammatory effects in animal models
- Studied in the thymus-neuroendocrine axis and age-related immune decline
Reference dosing by bodyweight
Anchored to the most-cited research dose (250 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 156–211 mcg |
| 60–75 kg / 132–165 lb | 191–259 mcg |
| 75–90 kg / 165–198 lb | 234–316 mcg |
| 90–105 kg / 198–231 lb | 276–374 mcg |
| >105 kg / >231 lb | 319–431 mcg |
Side effects to weigh against sleep benefit
- Not well characterized in humans
- Theoretical immune-modulation effects
- Activity depends on adequate zinc status
Also researched for
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.