SLU-PP-332 for Longevity
Investigational small-molecule ERR (estrogen-related receptor) agonist studied preclinically as an exercise mimetic. Mouse data only; no human studies. Educational use only.
Why SLU-PP-332 for longevity?
According to PubMed, SLU-PP-332 is a synthetic pan-ERR agonist (highest potency at ERR-alpha) that induced an acute aerobic-exercise genetic program and increased exercise endurance in mice (Billon C et al., ACS Chem Biol 2023), and reduced obesity and improved insulin sensitivity in mouse models of metabolic syndrome (Billon C et al., J Pharmacol Exp Ther 2024). All evidence is rodent; there are no human data.
Longevity context: Targeting senescent cells, mitochondrial function, telomere maintenance, and cellular resilience. SLU-PP-332 fits this goal because its category (Performance) and benefit profile align with the underlying mechanism.
Benefits relevant to longevity
- Preclinical: increased mitochondrial function and exercise endurance in mice
Reference dosing by bodyweight
Anchored to the most-cited research dose (250 mcg @ 75 kg). Reference only.
| Bodyweight band | Reference dose range |
|---|---|
| <60 kg / <132 lb | 156–211 mcg |
| 60–75 kg / 132–165 lb | 191–259 mcg |
| 75–90 kg / 165–198 lb | 234–316 mcg |
| 90–105 kg / 198–231 lb | 276–374 mcg |
| >105 kg / >231 lb | 319–431 mcg |
Side effects to weigh against longevity benefit
- Not established in humans (no clinical trials)
Also researched for
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.