SLU-PP-332
SLU-PP-332 is a synthetic agonist of the estrogen-related receptors (ERR-alpha, beta, gamma), orphan nuclear receptors that regulate mitochondrial biogenesis and oxidative metabolism in skeletal muscle. By activating ERR-alpha it reproduces parts of the transcriptional program normally triggered by aerobic exercise, increasing oxidative muscle fibers and endurance in mice. Its metabolic effects in rodents (reduced fat mass, improved insulin sensitivity) follow from this exercise-mimetic activity. Human relevance is unknown.
Onset and duration vary by individual; see the mechanism and half-life above.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
According to PubMed, SLU-PP-332 is a synthetic pan-ERR agonist (highest potency at ERR-alpha) that induced an acute aerobic-exercise genetic program and increased exercise endurance in mice (Billon C et al., ACS Chem Biol 2023), and reduced obesity and improved insulin sensitivity in mouse models of metabolic syndrome (Billon C et al., J Pharmacol Exp Ther 2024). All evidence is rodent; there are no human data.
Citations (2)
Last reviewed: 2026-06-15
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Research Protocols
Common DosagesHuman dosing
“Preclinical (mouse) only; no human regimen exists. Research and educational context only.”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Investigational exercise-mimetic for endurance and metabolic effects (preclinical)
- Research interest in obesity and metabolic syndrome (mouse models)
Key Research Benefits
- Preclinical: activates an acute aerobic-exercise gene program via ERR-alpha
- Preclinical: increased mitochondrial function and exercise endurance in mice
- Preclinical: reduced fat mass and improved insulin sensitivity in obese mouse models
Potential Side Effects
Considerations and Cautions
- No human safety data; not for human use outside research
- Avoid in pregnancy or breastfeeding (no data)
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated markers: No human studies exist; there are no established compound-specific labs to monitor.
Dose Calculator
Peptide Reconstitution Calculator
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SLU-PP-332 by goal
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Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.