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Glossary

Agonist

Substance that activates a receptor

An agonist is a substance that binds to a receptor and turns it on. The binding produces the response that the receptor normally creates when its natural signal arrives. Many research peptides are studied because they act as agonists at specific receptors.

Used in 19 research peptides

Metabolic
Tirzepatide
Weight & Glucose Manager.
Metabolic
Retatrutide
The 'Godzilla' of weight loss; a triple-hormone agonist for unprecedented fat loss and metabolic health.
Cosmetic
PT-141 (Bremelanotide)
Melanocortin agonist FDA-approved (Vyleesi) for HSDD; libido enhancement.
Metabolic
Cagrilintide
Amylin analog co-developed with semaglutide as 'CagriSema' for next-gen weight loss.
Performance
Anamorelin
Oral ghrelin-receptor agonist developed for cancer cachexia; approved in Japan as Adlumiz.
Performance
Capromorelin
Oral non-peptide ghrelin-receptor agonist; FDA-approved as a veterinary appetite stimulant.
Metabolic
Liraglutide
Daily GLP-1 analog; FDA-approved for diabetes (Victoza) and obesity (Saxenda®).
Metabolic
Dulaglutide
Weekly GLP-1 receptor agonist fused to an IgG4 Fc fragment; sold as Trulicity by Eli Lilly.
Metabolic
Lixisenatide
Short-acting prandial GLP-1 agonist; sold as Adlyxin/Lyxumia by Sanofi.
Metabolic
Survodutide
Investigational GLP-1 / glucagon dual agonist from Boehringer Ingelheim and Zealand Pharma.
Metabolic
Mazdutide
GLP-1 / glucagon dual agonist (Innovent / Eli Lilly) submitted in China for obesity 2024.
Metabolic
Orforglipron
First oral non-peptide GLP-1 receptor agonist (Eli Lilly); Phase 3 obesity program.
Recovery
Larazotide Acetate
Tight-junction regulator developed for celiac disease; reduces intestinal permeability.
Sleep
Orexin-A (Hypocretin-1)
Hypothalamic neuropeptide regulating wakefulness; intranasal investigation for narcolepsy.
Metabolic
Exenatide
First-in-class GLP-1 mimetic derived from Gila monster venom; sold as Byetta/Bydureon.
Metabolic
Albiglutide
Weekly GLP-1 agonist fused to albumin; discontinued GSK product (Tanzeum/Eperzan).
Metabolic
Retatrutide + Cagrilintide Stack
Investigational community stack pairing a triple incretin agonist with a long-acting amylin analog.
Metabolic
CagriSema (Cagrilintide + Semaglutide)
Investigational once-weekly fixed combination of the amylin analog cagrilintide and the GLP-1 agonist semaglutide, studied in the Phase 3 REDEFINE program for weight management.
Performance
SLU-PP-332
Investigational small-molecule ERR (estrogen-related receptor) agonist studied preclinically as an exercise mimetic. Mouse data only; no human studies. Educational use only.

See also

Receptor Antagonist Receptor Desensitization Analog

Educational use only

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