Semax · Cognitive
Semax dosage by bodyweight
Reference dose ranges scaled across bodyweight bands, anchored to the most-cited research dose (300 mcg @ 75 kg). Educational only, never a recommendation.
| Bodyweight band | Reference dose range | At U-100 (1 mg/mL) | Vol. on U-100 (5 mg / 2 mL) | 5× t½ elapsed |
|---|---|---|---|---|
| <60 kg / <132 lb | 187–253 mcg | 0.19–0.25 mL | 8–10 units0.07–0.10 mL | 1.0 h |
| 60–75 kg / 132–165 lb | 230–311 mcg | 0.23–0.31 mL | 9–12 units0.09–0.12 mL | 1.0 h |
| 75–90 kg / 165–198 lb | 281–379 mcg | 0.28–0.38 mL | 11–15 units0.11–0.15 mL | 1.0 h |
| 90–105 kg / 198–231 lb | 332–448 mcg | 0.33–0.45 mL | 13–18 units0.13–0.18 mL | 1.0 h |
| >105 kg / >231 lb | 383–518 mcg | 0.38–0.52 mL | 15–21 units0.15–0.21 mL | 1.0 h |
Volume column assumes a standard 5 mg vial reconstituted with 2 mL bacteriostatic water (concentration 2.5 mg/mL); insulin units shown for a U-100 syringe. Five half-lives is the conventional washout window where ~3% of peak plasma remains, a useful "next dose due" anchor for Semax (t½ 12 min).
Dose & PK references
Selected from the Semax bibliography for relevance to dosing and pharmacokinetics.
- The efficacy of semax in the treatment of patients at different stages of ischemic stroke
- Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II
- Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.