Semax
Semax is an ACTH(4-10) synthetic analogue developed in Russia that has been studied for neuroprotective and nootropic effects. Research in rodent models and Russian clinical studies suggests it upregulates BDNF and NGF expression in the hippocampus, modulates dopaminergic and serotonergic systems, and demonstrates cytoprotective effects in ischemic stroke models.
Cognitive effects may be perceived acutely to within days; sustained benefit depends on continued use.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Developed in Russia, it is used for the treatment of stroke and cognitive disorders. It increases BDNF levels.
Pharmacokinetics
- Half-life (t½)
- 15 min
- Approximate plasma half-life
- Routes
- IntranasalSubcutaneous
t½ 12 min · ~3% remaining at 1.0 h
Citations (7)
- The efficacy of semax in the treatment of patients at different stages of ischemic strokePubMed 2018
- Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan IIPubMed 2024
- Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodentsPubMed
- Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampusPubMed
- The neuroprotective effects of Semax in conditions of MPTP-induced lesions of the brain dopaminergic systemPubMed
- Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrainPubMed
- The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysisReview
Last reviewed: 2026-05-09
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Typical Dose Range Observed
Research Protocols
Common DosagesCognitive Focus
“Intranasal spray or SubQ injection”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Studied for cognitive enhancement and neuroprotection in Russian clinical research
- Investigated for potential benefits in ischemic stroke recovery
- Explored for stress resilience and BDNF modulation in preclinical models
Key Research Benefits
- Improves focus
- Enhances memory
- Neuroprotection
- Reduces stress
Potential Side Effects
Considerations and Cautions
- Limited large-scale Western RCT data; approved only in Russia
- Not approved in the US, EU, or most Western jurisdictions
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 0.10 mL on a U-100 syringe
Quick Explainer
Related Tools
Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.