HGH Fragment 176-191
HGH Fragment 176-191 is a modified form of the C-terminal region of human growth hormone, comprising amino acids 176-191. It has been studied for its reported ability to stimulate lipolysis in adipose tissue without inducing the pro-growth or insulin-resistance effects associated with intact GH. Preclinical evidence suggests it acts via a beta-adrenergic mechanism independent of the GH receptor.
Acute growth-hormone pulse within roughly 30 to 60 minutes of dosing; body-composition effects build over weeks.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
A modified form of amino acids 176-191 of the human growth hormone polypeptide.
Pharmacokinetics
- Half-life (t½)
- 30 min
- Approximate plasma half-life
- Routes
- Subcutaneous
Citations (5)
- Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragmentPubMed
- The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out micePubMed
- Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolismPubMed
- Reduction of cumulative body weight gain and adipose tissue mass in obese mice: response to chronic treatment with synthetic hGH 177-191 peptidePubMed
- Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormonePubMed
Last reviewed: 2026-05-09
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Typical Dose Range Observed
Research Protocols
Common DosagesFat Loss
“Ideally taken on an empty stomach before cardio”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Studied for selective lipolytic (fat-mobilizing) activity in adipose research models
- Investigated as a potential approach to visceral fat reduction without GH-related side effects
- Explored for anti-obesity research in animal studies
Key Research Benefits
- Fat loss
- Inhibits fatty acid formation
- No blood sugar impact
Potential Side Effects
Considerations and Cautions
- Limited human clinical trial data
- Not FDA-approved; classified as research-only
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- IGF-1: Primary downstream marker of growth-hormone-axis activity.
- Fasting glucose / HbA1c: GH-axis stimulation can reduce insulin sensitivity over time.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
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or 0.10 mL on a U-100 syringe
Quick Explainer
HGH Fragment 176-191 by goal
Read HGH Fragment 176-191's profile filtered through specific research goals.
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.