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111 compounds across peptides, hormones, and small molecules. 52 have full evidence profiles with mechanism summaries, evidence grades, and peer-reviewed citations. Information is for educational purposes only.
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Showing 22 of 111 compounds (10 with full profiles)
Small-molecule NNMT inhibitor that boosts NAD+ and white-fat mobilization.
Adipotide is a ligand-directed peptidomimetic: a cyclic CKGGRAKDC motif binds prohibitin on the endothelial cells that line white-adipose-tissue blood vessels, and a fused proapoptotic D(KLAKLAK)2 sequence disrupts mitochondrial membranes once internalized.
Weekly GLP-1 agonist fused to albumin; discontinued GSK product (Tanzeum/Eperzan).
Modified HGH fragment 176-191 analog targeted at fat loss without GH side effects.
Cagrilintide is a long-acting synthetic amylin analog that acts as an agonist at amylin receptors (AMY1, AMY2, AMY3) and the calcitonin receptor.
Semaglutide activates GLP-1 receptors to reduce appetite, slow gastric emptying, and improve glucose-dependent insulin secretion, while cagrilintide activates amylin receptors to promote satiety and slow gastric emptying.
Weekly GLP-1 receptor agonist fused to an IgG4 Fc fragment; sold as Trulicity by Eli Lilly.
First-in-class GLP-1 mimetic derived from Gila monster venom; sold as Byetta/Bydureon.
HGH Fragment 176-191 is a modified form of the C-terminal region of human growth hormone, comprising amino acids 176-191.
Daily GLP-1 analog; FDA-approved for diabetes (Victoza) and obesity (Saxenda®).
Short-acting prandial GLP-1 agonist; sold as Adlyxin/Lyxumia by Sanofi.
GLP-1 / glucagon dual agonist (Innovent / Eli Lilly) submitted in China for obesity 2024.
First oral non-peptide GLP-1 receptor agonist (Eli Lilly); Phase 3 obesity program.
Retatrutide (LY3437943) is a long-acting triple agonist developed by Eli Lilly that simultaneously activates GLP-1, GIP, and glucagon receptors.
Combines retatrutide's triple agonism at GLP-1, GIP, and glucagon receptors with cagrilintide's long-acting amylin receptor agonism.
Semaglutide is a GLP-1 receptor agonist approved for type 2 diabetes (Ozempic) and obesity management (Wegovy).
Investigational GLP-1 / glucagon dual agonist from Boehringer Ingelheim and Zealand Pharma.
Teduglutide is a recombinant analog of glucagon-like peptide-2 (GLP-2) with a Gly2 substitution that resists DPP-4 degradation, extending its activity relative to native GLP-2.
Tesamorelin is an FDA-approved synthetic analogue of GHRH indicated for HIV-associated lipodystrophy.
Triple monoamine reuptake inhibitor with strong weight-loss data; not FDA-approved.
Tesofensine paired with metoprolol (Tesomet) to control HR while preserving weight loss.
Tirzepatide is a dual GIP/GLP-1 receptor agonist approved by the FDA for type 2 diabetes (Mounjaro) and obesity (Zepbound).