Appetite or glycemic effects within the first days; full effect accrues over weeks to months alongside titration.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Mazdutide (IBI362, originally LY3305677) is a weekly GLP-1R/GCGR dual agonist licensed by Innovent from Eli Lilly for greater China. Phase 3 GLORY-1 (2024) reported ~14-15% mean weight loss at 48 weeks at the 6 mg dose. NMPA submission filed in China for obesity in 2024.
Citations (4)
- Mazdutide versus placebo in Chinese adults with type 2 diabetesReview
- Efficacy and Safety of Mazdutide in Chinese Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Phase 2 TrialReview
- Mazdutide, a dual agonist targeting GLP-1R and GCGR, mitigates diabetes-associated cognitive dysfunction: mechanistic insights from multi-omics analysisReview
- Mazdutide reduces body weight in adults with overweight or obesity: A high‐dose Phase 1 trialReview
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Research Protocols
Common DosagesInvestigational
“Phase 3 dosing in China”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Key Research Benefits
- Weight loss with energy expenditure boost
- Hepatic fat reduction
- Glucose control
Potential Side Effects
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- HbA1c: Primary glycemic efficacy marker for incretin therapy.
- Fasting glucose: Tracks glycemic response and hypoglycemia risk in combination therapy.
- Lipid panel / ApoB: Incretin therapy commonly improves atherogenic lipids alongside weight loss.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
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Mazdutide by goal
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.