Glossary
GLP-1
Gut hormone that slows digestion and promotes fullness
GLP-1 is a hormone released by cells lining the intestine after food enters the stomach. It signals the pancreas to release insulin when blood sugar rises and slows the speed at which the stomach empties its contents into the small intestine. Research compounds that activate the GLP-1 pathway are studied for how they influence appetite signals and blood sugar responses after meals.
Used in 13 research peptides
- MetabolicTirzepatideWeight & Glucose Manager.
- MetabolicRetatrutideThe 'Godzilla' of weight loss; a triple-hormone agonist for unprecedented fat loss and metabolic health.
- MetabolicSemaglutideThe GLP-1 pioneer for sustainable weight loss and cardiovascular health.
- MetabolicCagrilintideAmylin analog co-developed with semaglutide as 'CagriSema' for next-gen weight loss.
- MetabolicLiraglutideDaily GLP-1 analog; FDA-approved for diabetes (Victoza) and obesity (Saxenda®).
- MetabolicDulaglutideWeekly GLP-1 receptor agonist fused to an IgG4 Fc fragment; sold as Trulicity by Eli Lilly.
- MetabolicLixisenatideShort-acting prandial GLP-1 agonist; sold as Adlyxin/Lyxumia by Sanofi.
- MetabolicSurvodutideInvestigational GLP-1 / glucagon dual agonist from Boehringer Ingelheim and Zealand Pharma.
- MetabolicMazdutideGLP-1 / glucagon dual agonist (Innovent / Eli Lilly) submitted in China for obesity 2024.
- MetabolicOrforglipronFirst oral non-peptide GLP-1 receptor agonist (Eli Lilly); Phase 3 obesity program.
- MetabolicExenatideFirst-in-class GLP-1 mimetic derived from Gila monster venom; sold as Byetta/Bydureon.
- MetabolicAlbiglutideWeekly GLP-1 agonist fused to albumin; discontinued GSK product (Tanzeum/Eperzan).
- MetabolicCagriSema (Cagrilintide + Semaglutide)Investigational once-weekly fixed combination of the amylin analog cagrilintide and the GLP-1 agonist semaglutide, studied in the Phase 3 REDEFINE program for weight management.
See also
Educational use only
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