Larazotide Acetate
Tight-junction regulator developed for celiac disease; reduces intestinal permeability.
No acute perceptible effect; reported benefits build over days to weeks of consistent use.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Larazotide acetate (AT-1001) is an octapeptide zonulin antagonist that prevents tight-junction disassembly in the small intestine. Innovate Biopharmaceuticals advanced it to Phase 3 (CeDLara) as an adjunct for celiac disease but the trial failed its primary endpoint in 2022, and the program was paused. Still studied in long COVID and IBS.
Citations (4)
- Larazotide acetate: a pharmacological peptide approach to tight junction regulationPubMed
- Larazotide Acetate Protects the Intestinal Mucosal Barrier from Anoxia/Reoxygenation Injury via Various Cellular MechanismsReview
- The potential utility of tight junction regulation in celiac disease: focus on larazotide acetateReview
- Larazotide acetate for treatment of celiac disease: A systematic review and meta-analysis of randomized controlled trialsReview
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Research Protocols
Common DosagesCeliac (research)
“Before meals”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Key Research Benefits
- Tightens intestinal junctions
- Reduces leaky-gut markers
- Studied in celiac disease
Potential Side Effects
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 0.20 mL on a U-100 syringe
Stack Larazotide Acetatewith…
Curated stacking partners researched alongside Larazotide Acetate. Each link opens a dedicated stack page with combined benefits, side-effect overlap, and half-life considerations.
- Performance stackLarazotide Acetate + IpamorelinGentle GH releaser that amps muscle growth and fat loss without the harsh sides.
- Performance stackLarazotide Acetate + CJC-1295Pairs with Ipamorelin for sustained growth hormone spikes, ideal for body comp tweaks.
- Performance stackLarazotide Acetate + SermorelinMimics natural GH pulses to build lean mass and improve sleep/recovery.
- Performance stackLarazotide Acetate + MK-677 (Ibutamoren)Oral GH secretagogue that cranks appetite, muscle preservation, and bone density.
Larazotide Acetate by goal
Read Larazotide Acetate's profile filtered through specific research goals.
Related Tools
Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.