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DOSEVAULT
Sleep

Orexin-A (Hypocretin-1)

Hypothalamic neuropeptide regulating wakefulness; intranasal investigation for narcolepsy.

Molecular Profile
linear
33 AA Sequence
CAS
205599-75-3
Mol. weight
3562.1 g/mol
Formula
C152H243N47O44S4
Chain length
33 aa
Sequence
pEPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2
Onset and duration

Effects on sleep are typically felt the night of dosing.

Storage and reconstitution

Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.

Clinical Evidence

What the literature says

Scientific Overview

Orexin-A (hypocretin-1) is a 33-aa hypothalamic neuropeptide central to wakefulness; loss of orexin neurons causes narcolepsy type 1. Intranasal orexin-A has been studied as a replacement therapy in narcolepsy and for cognitive arousal in sleep deprivation (Baier et al., 2008). Small-molecule orexin agonists (e.g. TAK-861, Takeda) are in late-stage trials.

Citations (4)

  1. THE REGULATION OF SLEEP AND WAKEFULNESS BY THE HYPOTHALAMIC NEUROPEPTIDE OREXIN/HYPOCRETINReview
  2. Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward systemPubMed
  3. The role of orexin neuron activity in sleep/wakefulness regulationReview
  4. Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in miceReview

Research Guide

How users approach this compound

The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.

Research Protocols

Common Dosages

Research (intranasal)

Not established
Investigational

“Phase 1/2 only”

Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.

Key Research Benefits

  • Promotes wakefulness
  • Investigated in narcolepsy type 1
  • Potential cognitive arousal

Potential Side Effects

Insomnia if mistimed
Tachycardia (theoretical)
Limited approved use

Labs to monitor

Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.

  • No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.

Dose Calculator

Peptide Reconstitution Calculator

mg

Total amount of peptide in the vial.

mL

Volume of water used to mix.

mcg

Draw to this mark

10 Units

or 0.10 mL on a U-100 syringe

Concentration:2.50 mg/mL
Peptide per Unit:25.00 mcg/unit
*Always double-check your calculations. This tool is for educational purposes only.

Orexin-A (Hypocretin-1) by goal

Read Orexin-A (Hypocretin-1)'s profile filtered through specific research goals.

Orexin-A (Hypocretin-1) for SleepOrexin-A (Hypocretin-1) for Libido

Related Tools

Not medical advice

Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.