Palmitoyl Pentapeptide-4 (Matrixyl)
Original Matrixyl peptide; signals fibroblasts to upregulate collagen I/III and fibronectin.
Topical effects build gradually over weeks of consistent use.
Topical and cosmetic formulations: store per the product directions, typically cool and away from light; follow any beyond-use date.
Clinical Evidence
What the literature says
Scientific Overview
Palmitoyl Pentapeptide-4 (pal-KTTKS) is the original Matrixyl, developed by Sederma. The palmitoyl chain enhances stratum-corneum penetration; the KTTKS sequence is a procollagen I fragment that feedback-stimulates fibroblast collagen synthesis. Industry placebo-controlled trials show modest wrinkle-depth reduction at 4 ppm over 12 weeks.
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Research Protocols
Common DosagesTopical
“Leave-on serum/cream”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Key Research Benefits
- Collagen I/III synthesis
- Reduces fine lines
- Improves skin firmness
Potential Side Effects
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
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Palmitoyl Pentapeptide-4 (Matrixyl) by goal
Read Palmitoyl Pentapeptide-4 (Matrixyl)'s profile filtered through specific research goals.
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.