IGF-1 DES
Truncated IGF-1 with localized hypertrophic action; favored for site-specific bodybuilding research.
Acute growth-hormone pulse within roughly 30 to 60 minutes of dosing; body-composition effects build over weeks.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Des(1-3) IGF-1 lacks the first three residues; ~10× more potent at the IGF-1R locally because it doesn't bind IGFBPs. Short systemic half-life.
Citations (5)
- Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injectionPubMed
- Insulin-like growth factor-I (IGF-I) analogue, LR(3)IGF-I, ameliorates the loss of body weight but not of skeletal muscle during food restrictionPubMed
- Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated ratsPubMed
- Detection of LongR3 -IGF-I, Des(1-3)-IGF-I, and R3 -IGF-I using immunopurification and high resolution mass spectrometry for antidoping purposesPubMed
- Optimizing IGF-I for skeletal muscle therapeuticsReview
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Research Protocols
Common DosagesSite Injection
“Intramuscular, target site”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Key Research Benefits
- Localized muscle hyperplasia
- Stronger receptor binding than wild-type
Potential Side Effects
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- IGF-1: Primary downstream marker of growth-hormone-axis activity.
- Fasting glucose / HbA1c: GH-axis stimulation can reduce insulin sensitivity over time.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 0.01 mL on a U-100 syringe
Stack IGF-1 DESwith…
Curated stacking partners researched alongside IGF-1 DES. Each link opens a dedicated stack page with combined benefits, side-effect overlap, and half-life considerations.
- Recovery stackIGF-1 DES + BPC-157The recovery king; speeds up tendon, muscle, and gut healing for faster training turnarounds.
- Recovery stackIGF-1 DES + TB-500Boosts tissue repair and reduces inflammation, perfect for injury-prone athletes.
- Recovery stackIGF-1 DES + KPVAnti-inflammatory tripeptide derived from α-MSH; gut and skin healing without sedation.
- Recovery stackIGF-1 DES + Pentadeca Arginate (PDA)Arginate-salt analog of BPC-157 developed for improved injection stability and tissue repair.
IGF-1 DES by goal
Read IGF-1 DES's profile filtered through specific research goals.
Related Tools
Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.