DSIP
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide originally isolated from rabbit brain during slow-wave sleep induction. It has been studied for its potential role in sleep-wake cycle regulation, stress modulation, and hypothalamic-pituitary axis interaction. Pichia pastoris-secreted fusion peptides crossing the blood-brain barrier have been explored as delivery models in recent research.
Effects on sleep are typically felt the night of dosing.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
A neuropeptide that regulates sleep.
Pharmacokinetics
- Half-life (t½)
- 15 min
- Approximate plasma half-life
- Routes
- Subcutaneous
t½ 7 min · ~3% remaining at 36 min
Citations (6)
- Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse modelsPubMed 2024
- The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptidePubMed
- Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind studyPubMed
- Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behaviorPubMed
- The effect of delta sleep-inducing peptide on the EEG and power spectra in ratPubMed
- Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP)PubMed
Last reviewed: 2026-05-09
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Typical Dose Range Observed
Research Protocols
Common DosagesRestorative Sleep
“Best taken 30-60m before desired sleep”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Studied for potential sleep-onset modulation and slow-wave sleep facilitation in research models
- Investigated for stress-axis (HPA) modulation in animal studies
- Explored for antioxidant and cytoprotective properties in preclinical research
Key Research Benefits
- Deep sleep
- Stress reduction
- Pain relief
Potential Side Effects
Considerations and Cautions
- Very limited controlled human data; original studies primarily from 1970s-1980s
- Not approved for any indication
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
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or 0.10 mL on a U-100 syringe
Quick Explainer
DSIP by goal
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.