GHRP-2
GHRP-2 (pralmorelin) is a synthetic hexapeptide growth hormone secretagogue that activates the GHSR-1a receptor, stimulating GH release from the pituitary with greater potency than GHRP-6. It also has modest effects on cortisol and prolactin. Clinical phase II trials documented significant GH secretion, and it has been approved as a diagnostic agent for GH deficiency in Japan.
Acute growth-hormone pulse within roughly 30 to 60 minutes of dosing; body-composition effects build over weeks.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Hexapeptide GH secretagogue. Stronger pulse than GHRP-6, less appetite-stimulating; commonly stacked with CJC-1295.
Pharmacokinetics
- Half-life (t½)
- 30 min
- Approximate plasma half-life
- Routes
- Subcutaneous
Citations (6)
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic PerformancePubMed 2026
- Pharmacokinetics and pharmacodynamics of growth hormone-releasing peptide-2: a phase I study in childrenPubMed
- Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy menPubMed
- Growth hormone-releasing peptide-2 infusion synchronizes growth hormone, thyrotrophin and prolactin release in prolonged critical illnessPubMed
- Growth hormone-releasing peptides: clinical and basic aspectsPubMed
- Clinical Usefulness of the Growth Hormone-Releasing Peptide-2 (GHRP-2) Test for Evaluating GH Secretory CapacityPubMed
Last reviewed: 2026-05-09
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Typical Dose Range Observed
Research Protocols
Common DosagesGH Pulse
“Empty stomach; pre/post-workout common”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Studied for potent growth hormone secretagogue activity in research and diagnostic settings
- Investigated as a diagnostic agent for GH deficiency (approved in Japan)
- Explored for muscle preservation and body composition in aging research
Key Research Benefits
- GH release
- Lean mass support
- Less hunger than GHRP-6
Considerations and Cautions
- Elevates cortisol and prolactin more than selective GHRPs like ipamorelin
- Not FDA-approved; classified as research-only in most Western jurisdictions
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- IGF-1: Primary downstream marker of growth-hormone-axis activity.
- Fasting glucose / HbA1c: GH-axis stimulation can reduce insulin sensitivity over time.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 0.08 mL on a U-100 syringe
Stack GHRP-2with…
Curated stacking partners researched alongside GHRP-2. Each link opens a dedicated stack page with combined benefits, side-effect overlap, and half-life considerations.
- Recovery stackGHRP-2 + BPC-157The recovery king; speeds up tendon, muscle, and gut healing for faster training turnarounds.
- Recovery stackGHRP-2 + TB-500Boosts tissue repair and reduces inflammation, perfect for injury-prone athletes.
- Recovery stackGHRP-2 + KPVAnti-inflammatory tripeptide derived from α-MSH; gut and skin healing without sedation.
- Recovery stackGHRP-2 + Pentadeca Arginate (PDA)Arginate-salt analog of BPC-157 developed for improved injection stability and tissue repair.
GHRP-2 by goal
Read GHRP-2's profile filtered through specific research goals.
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.