Humanin
Mitochondrial-derived peptide that protects against amyloid-beta and metabolic stress.
No acute perceptible effect; intended for long-term cellular outcomes rather than immediate changes.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Humanin is a 24-aa peptide encoded within the mitochondrial 16S rRNA region, discovered by Hashimoto et al. (2001) as a factor protecting neurons from amyloid-beta-induced toxicity. Together with MOTS-c and the SHLPs, it is part of the mitochondrial-derived peptide family. Studied in Alzheimer's, atherosclerosis, and diabetes models; no approved indication.
Citations (4)
- The mitochondrial derived peptide humanin is a regulator of lifespan and healthspanPubMed
- Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in HumansPubMed
- Humanin and Its Pathophysiological Roles in Aging: A Systematic ReviewReview
- Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal NeuronsReview
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Research Protocols
Common DosagesResearch
“Animal studies typically 1-2 mg/kg”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Key Research Benefits
- Neuroprotection vs amyloid-beta
- Insulin sensitization
- Cytoprotective in mitochondrial stress
Potential Side Effects
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 0.10 mL on a U-100 syringe
Humanin by goal
Read Humanin's profile filtered through specific research goals.
Related Tools
Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.