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DOSEVAULT
Metabolic

Tesofensine

Triple monoamine reuptake inhibitor with strong weight-loss data; not FDA-approved.

Molecular Profile
small-molecule
1 AA Sequence
CAS
195875-84-4
Mol. weight
328.4 g/mol
Formula
C17H24Cl2N
Chain length
1 aa
Sequence
tesofensine (small molecule)
Onset and duration

Metabolic effects build over days to weeks of consistent use.

Storage and reconstitution

Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.

Clinical Evidence

What the literature says

Scientific Overview

Phase III trial (2010) showed ~10% weight loss at 0.5 mg/day. Original Alzheimer's program scrapped; revived for obesity in some regions (Mexico, Argentina).

Citations (3)

  1. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trialPubMed
  2. The effect of tesofensine on appetite sensations in obese patientsPubMed
  3. Tesofensine—a novel potent weight loss medicinePubMed

Research Guide

How users approach this compound

The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.

Research Protocols

Common Dosages

Daily Oral

0.25–0.5 mg
Daily AM

“Cycle 4–12 weeks; monitor cardiovascular”

Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.

Key Research Benefits

  • Significant weight loss
  • Appetite suppression
  • Energy boost

Potential Side Effects

Insomnia
Increased heart rate
Dry mouth
Mood effects

Labs to monitor

Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.

  • No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.

Dose Calculator

Peptide Reconstitution Calculator

mg

Total amount of peptide in the vial.

mL

Volume of water used to mix.

mcg

Draw to this mark

10 Units

or 0.10 mL on a U-100 syringe

Concentration:2.50 mg/mL
Peptide per Unit:25.00 mcg/unit
*Always double-check your calculations. This tool is for educational purposes only.

Tesofensine by goal

Read Tesofensine's profile filtered through specific research goals.

Tesofensine for Fat Loss

Related Tools

Not medical advice

Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.