Tesofensine + Metoprolol (Tesomet)
Tesofensine paired with metoprolol (Tesomet) to control HR while preserving weight loss.
Metabolic effects build over days to weeks of consistent use.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Tesomet is a fixed-dose combination of tesofensine (a triple monoamine reuptake inhibitor) with metoprolol developed by Saniona. The metoprolol component is intended to blunt cardiovascular activation while maintaining the weight-loss efficacy of tesofensine. Phase 2 trials in hypothalamic obesity and Prader-Willi syndrome reported significant weight loss.
Citations (3)
- Randomized controlled trial of Tesomet for weight loss in hypothalamic obesityPubMed
- ODP350 Safety and Efficacy of Tesomet over 48 Weeks of Treatment: Results From a 24-Week Phase 2, Randomized, Double-Blind Study With 24 Week Open-Label Extension in Adults With Hypothalamic ObesityReview
- Trial to Explore Use of Tesofensine Combination in Patients with Hypothalamic ObesityReview
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Research Protocols
Common DosagesInvestigational
“Phase 2 dosing”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Key Research Benefits
- Controls tesofensine-induced HR rise
- Preserves weight loss
- Studied in Prader-Willi and hypothalamic obesity
Potential Side Effects
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
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or 0.20 mL on a U-100 syringe
Tesofensine + Metoprolol (Tesomet) by goal
Read Tesofensine + Metoprolol (Tesomet)'s profile filtered through specific research goals.
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.