Glossary
Off-Label
Use outside an approved indication
Off-label refers to the use of a medication for a purpose, dose, route, or patient population that was not part of the data submitted for its regulatory approval. Approval is granted only for the specific conditions studied. Any other use falls outside the approved labeling.
Used in 7 research peptides
- PerformanceGonadorelinSynthetic decapeptide identical to endogenous GnRH that stimulates the pituitary to release LH and FSH; used diagnostically and, off-label, to support the gonadal axis during testosterone therapy.
- PerformanceHCG (Human Chorionic Gonadotropin)Glycoprotein hormone with LH-mimetic activity that stimulates gonadal steroidogenesis; FDA-approved for cryptorchidism, select male hypogonadotropic hypogonadism, and ovulation induction.
- OtherOxytocinNine-amino-acid neuropeptide hormone; FDA-approved as an injectable for obstetric use, and studied off-label as an intranasal agent for social, anxiety, and sexual-health applications with mixed results.
- OtherVIP (Vasoactive Intestinal Peptide)A 28-amino-acid signaling peptide with anti-inflammatory and vasodilatory actions; its synthetic form (aviptadil) has been trialed for respiratory failure, and an intranasal form is used off-label in the chronic-inflammatory-response (mold/CIRS) community.
- TRTClomipheneClomiphene citrate is a nonsteroidal SERM consisting of a mixture of enclomiphene (trans) and zuclomiphene (cis) isomers. It is FDA-approved for ovulation induction in women; its use in males to raise endogenous testosterone is off-label.
- TRTAnastrozoleAnastrozole (Arimidex) is a potent, selective non-steroidal aromatase inhibitor. It is FDA-approved for breast cancer in postmenopausal women; its use in males to manage estradiol levels during testosterone therapy is off-label.
- TRTTamoxifenTamoxifen (Nolvadex) is a nonsteroidal SERM and the primary approved endocrine therapy for hormone receptor-positive breast cancer. Its use in males during or after testosterone therapy to manage gynecomastia or restore the hypothalamic-pituitary axis is off-label.
See also
Educational use only
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