Sermorelin
Sermorelin (GHRH 1-29 NH2) corresponds to the first 29 amino acids of endogenous growth hormone-releasing hormone and has been studied for its ability to stimulate pulsatile GH secretion from the anterior pituitary. It is FDA-approved as a diagnostic agent for GH deficiency and has been prescribed off-label for adult GH deficiency. Unlike synthetic GH, it acts upstream at the hypothalamic-pituitary axis, preserving endogenous feedback.
Acute growth-hormone pulse within roughly 30 to 60 minutes of dosing; body-composition effects build over weeks.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Sermorelin corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH).
Pharmacokinetics
- Half-life (t½)
- 10 min
- Approximate plasma half-life
- Routes
- Subcutaneous
t½ 12 min · ~3% remaining at 1.0 h
Citations (6)
- Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatographyPubMed 2026
- Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?PubMed
- Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiencyPubMed
- Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and womenPubMed
- A comparative study of growth hormone (GH) and GH-releasing hormone(1-29)-NH2 for stimulation of growth in children with GH deficiencyPubMed
- Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study GroupPubMed
Last reviewed: 2026-05-09
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Typical Dose Range Observed
Research Protocols
Common DosagesNatural Pulse
“Mimics natural GH release cycle”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Studied for stimulation of physiologic growth hormone pulses
- Investigated as an off-label alternative to recombinant GH for adults with GH deficiency
- Explored for age-related body composition and sleep quality research
Key Research Benefits
- Increases lean body mass
- Improves sleep quality
- Reduces body fat
- Enhances immune function
Potential Side Effects
Considerations and Cautions
- Contraindicated in confirmed active neoplasia
- Use in pregnancy not established
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- IGF-1: Primary downstream marker of growth-hormone-axis activity.
- Fasting glucose / HbA1c: GH-axis stimulation can reduce insulin sensitivity over time.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 0.10 mL on a U-100 syringe
Quick Explainer
Stack Sermorelinwith…
Curated stacking partners researched alongside Sermorelin. Each link opens a dedicated stack page with combined benefits, side-effect overlap, and half-life considerations.
- Recovery stackSermorelin + BPC-157The recovery king; speeds up tendon, muscle, and gut healing for faster training turnarounds.
- Recovery stackSermorelin + TB-500Boosts tissue repair and reduces inflammation, perfect for injury-prone athletes.
- Recovery stackSermorelin + KPVAnti-inflammatory tripeptide derived from α-MSH; gut and skin healing without sedation.
- Recovery stackSermorelin + Pentadeca Arginate (PDA)Arginate-salt analog of BPC-157 developed for improved injection stability and tissue repair.
Sermorelin by goal
Read Sermorelin's profile filtered through specific research goals.
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.