TB-500
TB-500 is a synthetic peptide fragment of Thymosin Beta-4, a 43-amino-acid protein ubiquitously expressed in mammalian cells. It has been studied for its role in actin sequestration and promoting cell migration, angiogenesis, and wound healing. Research suggests it reduces inflammatory cytokines and promotes myocardial and musculoskeletal tissue repair in animal models.
No acute perceptible effect; reported benefits build over days to weeks of consistent use.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Thymosin Beta-4 is a naturally occurring peptide present in almost all animal and human cells. TB-500 is its synthetic fragmented form, primarily researched for tissue regeneration and anti-inflammatory effects.
Pharmacokinetics
- Half-life (t½)
- 1.0 d
- Approximate plasma half-life
- Routes
- SubcutaneousIntramuscular
t½ 2.0 d · ~3% remaining at 10 d
Citations (7)
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic PerformancePubMed 2026
- Thymosin beta4 accelerates wound healingPubMed
- The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patientsPubMed
- Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applicationsPubMed
- Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle developmentPubMed
- Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometryPubMed
- Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptidePubMed
Last reviewed: 2026-05-09
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Typical Dose Range Observed
Research Protocols
Common DosagesHealing Protocol
“Often cycled for 4-8 weeks”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Studied for acceleration of soft-tissue and muscle injury recovery in preclinical models
- Investigated for anti-inflammatory effects at injury sites
- Explored for wound healing and tissue regeneration research
Key Research Benefits
- Boosts tissue repair
- Reduces inflammation
- Improves flexibility
- Promotes cell migration
Potential Side Effects
Considerations and Cautions
- No large-scale human safety data; off-label use only
- Theoretical caution in active cancer due to pro-angiogenic activity
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 1.00 mL on a U-100 syringe
Quick Explainer
Stack TB-500with…
Curated stacking partners researched alongside TB-500. Each link opens a dedicated stack page with combined benefits, side-effect overlap, and half-life considerations.
- Performance stackTB-500 + IpamorelinGentle GH releaser that amps muscle growth and fat loss without the harsh sides.
- Performance stackTB-500 + CJC-1295Pairs with Ipamorelin for sustained growth hormone spikes, ideal for body comp tweaks.
- Performance stackTB-500 + SermorelinMimics natural GH pulses to build lean mass and improve sleep/recovery.
- Performance stackTB-500 + MK-677 (Ibutamoren)Oral GH secretagogue that cranks appetite, muscle preservation, and bone density.
TB-500 by goal
Read TB-500's profile filtered through specific research goals.
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.