Epithalamin
Pineal-gland polypeptide extract; predecessor of Epitalon used in Russian gerontology.
No acute perceptible effect; intended for long-term cellular outcomes rather than immediate changes.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
Epithalamin is a pineal polypeptide extract from calf pineal gland developed in the Soviet Union by Khavinson and Anisimov from the 1970s. Reported to extend lifespan in mice, rats, and Drosophila in long-running St. Petersburg studies. The synthetic tetrapeptide Epitalon (Ala-Glu-Asp-Gly) was developed as the chemically defined successor.
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Research Protocols
Common DosagesHistorical (Russia)
“Largely replaced by Epitalon”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Key Research Benefits
- Reported extension of lifespan in Russian rodent studies
- Melatonin-axis modulation
Potential Side Effects
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- No validated compound-specific markers: No standard bloodwork is established for this compound; general safety labs (CBC, comprehensive metabolic panel) are reasonable if used under medical supervision.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 4.00 mL on a U-100 syringe
Epithalamin by goal
Read Epithalamin's profile filtered through specific research goals.
Related Tools
Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.