GHRP-6
GHRP-6 is a synthetic hexapeptide GH secretagogue that potently stimulates the GHSR-1a receptor (ghrelin receptor), triggering pulsatile GH release. Unlike ghrelin itself, it does not activate GH-independent metabolic pathways to the same extent. It also stimulates appetite via hypothalamic action. Preclinical research has documented GH pulse amplification and modest elevation of IGF-1 in rodent models.
Acute growth-hormone pulse within roughly 30 to 60 minutes of dosing; body-composition effects build over weeks.
Store the lyophilized powder refrigerated (2 to 8 C), or frozen for long-term storage, protected from light. After reconstitution with bacteriostatic water, keep refrigerated and use within about 4 weeks.
Clinical Evidence
What the literature says
Scientific Overview
A hexapeptide that acts on the hypothalamus and pituitary gland.
Pharmacokinetics
- Half-life (t½)
- 30 min
- Approximate plasma half-life
- Routes
- Subcutaneous
Citations (7)
- Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in RatsPubMed 2025
- On the actions of the growth hormone-releasing hexapeptide, GHRPPubMed
- Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin actionPubMed
- Growth hormone releasing hexapeptide (GHRP-6) activates the inositol (1,4,5)-trisphosphate/diacylglycerol pathway in rat anterior pituitary cellsPubMed
- Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulationPubMed
- Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrumPubMed
- Synthetic Growth Hormone-Releasing Peptides (GHRPs): A Historical Appraisal of the Evidences Supporting Their Cytoprotective EffectsReview
Last reviewed: 2026-05-09
Research Guide
How users approach this compound
The following reflects patterns observed in research literature and community protocols. This is not medical advice and does not constitute a clinical recommendation.
Typical Dose Range Observed
Research Protocols
Common DosagesHunger Pulse
“Take in a fasted state; avoid fat/carbs 30m before/after”
Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.
Reported Uses
- Studied for GH secretagogue activity in research and early clinical models
- Investigated for appetite stimulation in cachexia models via ghrelin receptor pathways
- Explored in combination with CJC-1295 for synergistic GH pulse amplification
Key Research Benefits
- Increases GH release
- Increases appetite
- Recovery
Potential Side Effects
Considerations and Cautions
- Pronounced appetite stimulation may be undesirable in some contexts
- Not FDA-approved; classified as research-only
Labs to monitor
Educational context only, not a testing mandate. Any bloodwork decisions belong with your clinician.
- IGF-1: Primary downstream marker of growth-hormone-axis activity.
- Fasting glucose / HbA1c: GH-axis stimulation can reduce insulin sensitivity over time.
Dose Calculator
Peptide Reconstitution Calculator
Total amount of peptide in the vial.
Volume of water used to mix.
Draw to this mark
or 0.10 mL on a U-100 syringe
Quick Explainer
Stack GHRP-6with…
Curated stacking partners researched alongside GHRP-6. Each link opens a dedicated stack page with combined benefits, side-effect overlap, and half-life considerations.
- Recovery stackGHRP-6 + BPC-157The recovery king; speeds up tendon, muscle, and gut healing for faster training turnarounds.
- Recovery stackGHRP-6 + TB-500Boosts tissue repair and reduces inflammation, perfect for injury-prone athletes.
- Recovery stackGHRP-6 + KPVAnti-inflammatory tripeptide derived from α-MSH; gut and skin healing without sedation.
- Recovery stackGHRP-6 + Pentadeca Arginate (PDA)Arginate-salt analog of BPC-157 developed for improved injection stability and tissue repair.
GHRP-6 by goal
Read GHRP-6's profile filtered through specific research goals.
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Not medical advice
Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.