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DOSEVAULT

Best peptides for longevity

Targeting senescent cells, mitochondrial function, telomere maintenance, and cellular resilience. The list below is ranked by strength of evidence, strongest first. Each entry links to a full profile with mechanism, dosing, and primary-source citations.

Ranking reflects the quality of available research, not a clinical recommendation. This is educational content, not medical advice.

  1. 1

    Tesamorelin

    Trims visceral fat while boosting IGF-1 levels, great for shredded longevity looks.

    • Reduces visceral fat
    • Increases IGF-1
    • Improves lipid profile
    Strong
  2. 2

    SS-31

    Targets mitochondria for energy surges, endurance, and anti-aging cellular repair.

    • Mitochondrial repair
    Moderate
  3. 3

    Epitalon

    Longevity star; lengthens telomeres to fight aging and support overall vitality.

    • Telomere lengthening
    • Anti-aging effects
    Limited
  4. 4

    MOTS-c

    Mitochondrial-derived peptide that improves insulin sensitivity and exercise capacity.

    • Mitochondrial efficiency
    Preclinical
  5. 5

    SLU-PP-332

    Investigational small-molecule ERR (estrogen-related receptor) agonist studied preclinically as an exercise mimetic. Mouse data only; no human studies. Educational use only.

    • Preclinical: increased mitochondrial function and exercise endurance in mice
    Preclinical
  6. 6

    Acetyl Tetrapeptide-2

    Anti-aging tetrapeptide marketed for thymopoietic skin remodeling and firmness.

    • Skin firmness
    • Reduces sagging around eyes
    • Marketed as 'thymus-mimetic'
  7. 7

    Epithalamin

    Pineal-gland polypeptide extract; predecessor of Epitalon used in Russian gerontology.

    • Reported extension of lifespan in Russian rodent studies
  8. 8

    FOXO4-DRI

    Senolytic D-retro-inverso peptide that disrupts FOXO4-p53 to selectively kill senescent cells.

    • Selective senolysis
    • Restored fitness in aged mice
    • Hair regrowth (mouse studies)
  9. 9

    GDF-11

    TGF-beta family ligand controversially linked to age-reversal via parabiosis studies.

    • Possible muscle/cardiac rejuvenation (debated)
    • Neurogenesis (preclinical)
  10. 10

    Glutathione

    Antioxidant Powerhouse.

    • Master antioxidant
    • Detoxification
    • Skin brightening
  11. 11

    HGH

    Growth Hormone Essentials.

    • Anti-aging
  12. 12

    Humanin

    Mitochondrial-derived peptide that protects against amyloid-beta and metabolic stress.

    • Cytoprotective in mitochondrial stress
  13. 13

    Klotho (alpha-Klotho)

    Anti-aging hormone; soluble klotho boosts cognition and modulates phosphate/FGF23 axis.

    • Cognitive enhancement (preclinical)
    • Phosphate homeostasis
    • Anti-fibrotic in kidney models
  14. 14

    Pinealon

    Khavinson tripeptide (Glu-Asp-Arg) marketed for pineal/CNS gerontoprotection.

    • Claimed neuroprotection
    • Studied in age-related cognitive decline (Russia)
  15. 15

    Vesugen

    Khavinson tripeptide (Lys-Glu-Asp) marketed as a vascular bioregulator.

    • Claimed endothelial support
    • Studied in atherosclerosis (Russia)

Not medical advice

Information on DoseVault is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a qualified healthcare provider.